Laboratory Monitoring of Cyclosporine Pre-dose Concentration (C0) After Kidney Transplantation in Isfahan

laboratory monitoring of cyclosporine pre-dose concentration (c0) after kidney transplantation in isfahan

background: cyclosporine is the main immunosuppressive agent used in organ transplantation which leads to considerable improvement in graft survival.  the large inter- and intra- patient variability in cyclosporine pharmacokinetics coupled with the agent’s narrow therapeutic index and adverse effects necessitate therapeutic monitoring of cyclosporine blood levels.   objective: the aim of this s...

The Relationship between the Plasma Level of Cyclosporine-A and Drug Dose in Patients of Kermanshah Kidney Transplantation Center

Background: Nowadays the main problem in transplantation is the complexity of host immune system protection against the immunological and destructive reactions of the transplanted organ. High serum level of the immunosuppressive drug may cause toxicity and low serum level leads to the rejection of the transplanted organ. Cyclosporine has been known as the most effective immunosuppressive drug. ...

Two-hour post-dose cyclosporine monitoring does not fit all in kidney transplantation

Cyclosporine C0- versus C2-monitoring over three years in maintenance heart transplantation.

INTRODUCTION There is an ongoing discussion as to whether monitoring of cyclosporine (CsA)-based immunosuppression with plasma levels two hours after medication intake (C2) offers clinical benefit over the measurement of CsA trough levels (C0) in patients after heart transplantation (HTx). In particular, data from long-term maintenance patients are not available. METHODS C0 monitoring was per...

change of cyclosporine absorption over the time after kidney transplantation

background although the immunosuppressant cyclosporine (csa) is widely used after kidney transplantation over the long term, there is still no firm consensus on the best way to monitor of csa blood levels. objectives cyclosporine (csa) assay is critical for the management of renal transplant recipients due to inter– and intra–patient variation in csa absorption and metabolism. patients and meth...

NINE CASES OF MALIGNANCY AFTER KIDNEY TRANSPLANTATION

Renal transplantation is considered one of the best long-term therapies for chronic renal failure, but unfortunately the incidence of malignancy significantly increases in renal transplant recipients. We analyzed nine cases of malignancy in 200 renal transplant recipients occurring in a 12-year follow-up in Imam hospital of Tehran University, Tehran, Iran. According to this study, the organ...